Research on burnout in European university students has explored its relation to personality traits and social support, however not in a combined model. Therefore, this study was set to examine the association among burnout, personality and social support and secondly, whether personality and social support can predict students’ burnout. The participants, completed three questionnaires; the Maslach Burnout Inventory Student-Survey (MBI-SS), the NEO Five-Factor Inventory (NEO-FFI) and the Multidimensional Scale of Perceived Social Support (MSPSS). The results indicated that all burnout’s components are significantly associated to neuroticism, extraversion and conscientiousness, whereas social support is releated only to academic inefficacy. Academic inefficacy was predicted by conscientiousness, cynicism was predicted by conscientiousness, whereas agreeableness and emotional exhaustion was predicted by neuroticism. Social support did not predict independently any component of burnout. It was concluded that conscientiousness, agreeableness and neuroticism can influence burnout symptoms among European students.